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SIBA® (Strand Invasion Based Amplification) is Orion Diagnostica’s proprietary isothermal nucleic acid amplification technology. The technology is based on amplification of nucleic acids at a constant temperature of 40 degrees Celsius.

Please click the area below to see how the SIBA technology works:



Documents and materials

SIBA licensing and partnering opportunities (GB)

Scientific articles

Hoser MJ, Mansukoski HK, Morrical SW, Eboigbodin KE (2014) Strand Invasion Based Amplification (SIBA®): A Novel Isothermal DNA Amplification Technology Demonstrating High Specificity and Sensitivity for a Single Molecule of Target Analyte. PLoS ONE 9(11): e112656. doi:10.1371/journal.pone.0112656A

Eboigbodin KE & Hoser MJ (2016). Multiplex Strand Invasion Based Amplification (mSIBA) assay for detection of Chlamydia trachomatis and Neisseria gonorrhoeae. Scientific Reports, 6, 20487. Doi: 10.1038/srep20487

Eboigbodin K, Filén S, Ojalehto T, Brummer M, Elf S, Pousi K & Hoser M. Reverse transcription strand invasion based amplification (RT-SIBA): a method for rapid detection of influenza A and B Applied Microbiology and Biotechnology, 2016, April 11. Doi: 10.1007/s00253-016-7491-y.


SIBA Poster MDE 2016 (GB)

SIBA Poster EMMD 2015 (GB)

SIBA Poster RME 2015 (GB)


Orion GenRead is based on the SIBA technology. Read more about Orion GenRead.