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Clostridium difficile is the major cause of healthcare-associated infections (HAIs)

The incidence of C. difficile infection (CDI) is rising globally at an accelerating rate and CDI has become more severe and difficult to treat (1–5). CDI is now clearly more common than HAIs caused by methicillin-resistantStaphylococcus aureus (MRSA) (6–8). Urgent action is needed to improve the management of CDI.

Read more about CDI, clinical and economic burden of CDI and how diagnostic delays consume healthcare resources: Clostridium difficile is the major cause of healthcare-associated infections (HAIs) 

Read about Orion GenRead C. difficile - Make the most of your resources



  1. Davies KA. Underdiagnosis of Clostridium difficile across Europe: the European, multicenter, prospective, biannual, point-prevalence study of Clostridium difficile infection in hopsitalised patients with diarrhea (EUCLID). Lancet Infect Dis 2014;14:1208-19.
  2. Magill SS et al. Multistate Point-Prevalence Survey of Health Care-Associated Infections. N Engl J Med 2014;370:1198-208.
  3. Reveles KR et al. The rise in Clostridium difficile infection incidence among hospitalized adults in the United States: 2001-2010. 
    Am J Infect Control. 2014;42(10):1028-32.
  4. Bauer MP et al. Clostridium difficile infection in Europe: a hospital-based survey. Lancet 2011;377:63-73.
  5. Crobach MJ et al. European Society of Clinical Microbiology and Infectious Diseases (ESCMID): data review and recommendations for diagnosing Clostridium difficile-infection (CDI). Clin Microbiol Infect. 2009;15(12):1053-66.
  6. UK Health Protection Agency. English national point prevalence survey on healthcare-associated infections and antimicrobial use, 2011: preliminary data. London; Health Protection Agency, 2012
  7. Meyer E et al. Associations between nosocomial meticillin-resistant Staphylococcus aureus and nosocomial Clostridium difficile-associated diarrhoea in 89 German hospitals. J Hosp Infect. 2012;82(3):181-6.
  8. Miller BA et al. Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals. Infect Control Hosp Epidemiol 2011;32:387-90.