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New QuikRead go CRP publication!

QuikRead go CRP POCT test shows high negative predictive value to rule out severe bacterial infection among children 1-24 months of age presenting to the emergency department with fever of unknown origin.

A new QuikRead go CRP study has been published on-line in the European Journal of Clinical Microbiology & Infectious Diseases. The QuikRead go CRP test was used to find an optimal cut-off to rule out the possibility of serious bacterial infection (SBI) and to make a comparison against the laboratory CRP method (Architect c8000 Abbott, Germany). The study population consisted of children aged 1-24 months. Both fingerstick and heelprick samples were used.

The best cut-off value for ruling out the possibility of SBI was <10 mg/l. Using this cut-off value the probablilty of SBI was very low, 2 %, meaning that the QuikRead go CRP test had a high negative predictive value (NPV). Although a cost-effectiveness evaluation was not specifically performed, the authors estimated a positive cost-benefit for the QuikRead go CRP test due to avoiding costs due to additional laboratory tests as well as avoiding costs due to increased length of stay (LOS) at the emergency depertment (ED).

The study concluded that the QuikRead go CRP test performed on  capillary blood samples provides precise and reliable results. The correlation to the lab method was good. “Thus, we believe that implementation of CRP POCT could substantially optimize the management of infants with fewer without source at the ED. To identify those patients at a low risk of SBI would optimize the patient flow at the ED, especially during the busiest periods of service demand.”