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The UniQ Bone & Tissue Markers are unique serum tests for measuring collagen metabolism in bone and soft tissues.

The quantitative UniQ PINP RIA test measures intact aminoterminal propeptide of type I procollagen liberated into the blood stream during bone formation.

The quantitative UniQ ICTP RIA test measures carboxyterminal cross-linked telopeptide of type I collagen liberated into the blood stream during pathological bone degradation.

The quantitative UniQ PIIINP RIA test measures intact aminoterminal propeptide of type III procollagen, an indicator of soft tissue metabolism.


PINP - aminoterminal propeptide of type I procollagen - is a specific type I collagen metabolite which is liberated into the blood stream during the formation of new bone. Its concentration is directly related to the rate of bone turnover. In metabolic bone diseases such as osteoporosis, PINP is a sensitive indicator for identifying patients with a high rate of bone turnover and, consequently, at high risk of fracture. PINP is a useful parameter for monitoring the effectiveness of anti-resorptive and anabolic treatment.

ICTP - carboxyterminal telopeptide of type I collagen - is a crosslinked product of collagen degradation, which is released from bone when it is being degraded under pathological conditions.

ICTP can be used to monitor diseases involving pathological degradation of bone, such as cancers that metastasise to bone, rheumatoid arthritis and multiple myeloma.

PIIINP - aminoterminal propeptide of type III procollagen - is liberated into the circulation during soft tissue formation. Changes in PIIINP levels reflect the involvement and altered metabolism of type III collagen, which is common in many connective tissue disorders.

PIIINP can be used to assess and monitor fibrotic processes in liver diseases, thus avoiding the need for liver biopsies. It is also useful for monitoring growth hormone therapy in children with growth disorders. PIIINP gives prognostic information on cardiac disease and reflects the healing process.

UniQ tests provide you with

A specific and sensitive means for assessing the metabolism of bone and soft tissues.


  • Monitoring the effect of osteoporosis treatment
  • Selecting the most effective treatment
  • Monitoring patient compliance
  • A dynamic marker showing the rate of bone turnover
  • Changes in bone turnover seen in a couple of months


  • Early detection of skeletal bone metastases in breast, lung and prostate cancers
  • Detection of minor changes in bone turnover much earlier than bone scan
  • Reveals osteolytic bone lesions in multiple myeloma years before they are radiologically detectable
  • Early detection of rheumatoid patients needing intensified treatment


  • Monitoring of fibrosis, especially in the liver and heart
  • Patient-friendly, non-invasive method for monitoring methotrexate treated psoriatics
  • Bringing cost savings to health economy by decreasing the need for liver biopsies
  • Prognostic marker in cardiac failures

Test results should never be used alone, without a complete clinical evaluation.

UniQ PINP RIA registered in the USA. UniQ PIIINP RIA and UniQ ICTP RIA are not registered in the USA. 


Technical data

Products available
Use For in vitro diagnostic use


Sample type Serum
Time to result Approx. 4 hours
Reading of the result Gamma counter

Detection limit: PINP approx. 2 µg/l, ICTP approx. 0.6 µg/l, PIIINP approx. 0.3 µg/l


PINP: 2.7 % cross-reactivity with small monomeric degradation products (col1), no cross-reactivity with PIIINP. ICTP: no cross-reactivity with other UniQ antigens. PIIINP: no cross-reactivity with PINP.

Storage +2...+8 °C
Additionally needed

Gamma counter


UniQ PINP RIA registered in the USA.
UniQ PIIINP RIA and UniQ ICTP RIA are not registered in the USA.

Registered trademark UniQ is a registered trademark of Orion Diagnostica Oy.

About the tests

Collagen is the most common protein in the human body. It provides structural support to bone, skin, muscle and tendons. Monitoring the metabolism of collagen from serum samples can be used to detect and manage a range of different bone and soft tissue disorders.

Increased serum concentrations of ICTP are seen in conditions associated with increased lysis of bone, such as multiple myeloma, osteolytic metastases, rheumatoid arthritis and immobilisation. PINP measurements provide a sensitive tool for assessing increased bone turnover in postmenopausal women and may be particularly useful for monitoring the effect of antiresorptive and anabolic therapy on bone metabolism. Liver fibrosis and cirrhosis of various aetiologies increase serum concentrations of PIIINP. PIIINP provides a non-invasive means of monitoring the effect of methotrexate treatment on the livers of psoriasis patients. 

More information

The UniQ PINP kit is intended to be used as an aid in the management of postmenopausal osteoporosis. Short-term changes in PINP are associated with longer-term changes in bone mineral density in postmenopausal women. Monitoring PINP concentrations during osteoporosis treatment provides a rapid assessment of a patient’s response to osteoporosis therapy.

UniQ ICTP is an early marker of bone metastases in breast, lung and prostate cancer. It becomes elevated months before lesions become radiologically detectable.

The UniQ PIIINP test provides a means of monitoring development of fibrosis, especially in the liver and heart, in a patient-friendly and cost-effective way.

Documents and materials

Marketing and sales materials

UniQ PINP RIA Data Sheet (GB)

UniQ PIIINP RIA Data Sheet (GB)

UniQ ICTP RIA Datasheet (GB)

UniQ Bone and Tissue Markers Family Brochure (GB)

UniQ PINP RIA Application Sheet Monitoring Osteoporosis (GB)

UniQ PIIINP RIA Application Sheet Liver Fibrosis (GB)

UniQ PIIINP RIA Application Sheet Cardiac Disease (GB)

UniQ ICTP RIA Application Sheet Bone Metastases (GB)


Monitoring treatment of methotrexate in psoriasis patients

The value of PINP measurements in the diagnosis and treatment of osteoporosis

Instructions for use

(For informative use only. Kindly always refer to the latest package insert in the kit.)

UniQ PINP RIA IFU (GB, DE, FR, NL, ES, IT, CZ, PL, SE, NO, DK), 67034


UniQ ICTP RIA IFU (GB, DE, FR, NL, ES, IT, CZ, PL, SE, NO, DK), 68601

Safety Data Sheet




Frequently asked questions

What types of test tube should be used when running the UniQ RIA kits?
We recommend using polystyrene test tubes for the UniQ PINP RIA and ICTP RIA assays. For UniQ PIIINP RIA both polystyrene and polypropylene test tubes can be used.

How are the collagen markers cleared from the blood circulation? Are there any conditions which can affect their clearance from the patient?
PINP and PIIINP are cleared from the circulation through a specialised part of the reticulo-endothelial system, the endothelial cells of the liver. These cells bind and internalise the propeptides by receptor-mediated endocytosis using scavenger receptors. Severe liver disease can affect the clearance of PINP and PIIINP. As renal insufficiency does not affect the concentration of the propeptides they are very useful for monitoring changes in collagen metabolism in patients with renal failure.
ICTP is cleared from the circulation through the kidneys. Renal insufficiency does not greatly affect the circulating concentration of ICTP because a glomerular filtration rate of two-thirds of the normal rate is still sufficient to remove ICTP. When the glomerular filtration rate is 50 ml/min/1.73 m2 or less, the ICTP concentration in blood becomes elevated.

What is the best way to process the results of UniQ assays?
The best way to process the results is to use spline function curve fitting with a linear Y-axis and a logarithmic X-axis.

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